2. How are DIDP and DINP used-GreenFacts Chile

  • 2. How are DIDP and DINP used-GreenFacts Chile
  • 2. How are DIDP and DINP used-GreenFacts Chile
  • 2. How are DIDP and DINP used-GreenFacts Chile
  • How many producers of DIDP & DINP are there?
  • There are currently four producers of DIDP and DINP in the European Union. The estimated production in 1994 was around 200 000 tonnes of DIDP and 107 000 tonnes of DINP per year (for the then twelve EU Member States) and the amounts have probably increased since then. Around 95% of DIDP and DINP is used in PVC as a plasticizer.
  • How many producers of DINP are there in the EU?
  • Approximately four producers of DINP exist in the EU. The estimated consumption volume in 1994 was ca. 107,200 t/a. An increase of the consumption of DINP is to be expected over the following years. Nearly all (95%) of DINP is used in PVC as a plasticizer. The remaining 5% are used in non-PVC applications.
  • What is the difference between DIDP and DINP?
  • Both DIDP and DINP can cause developmental toxicity and liver damage, but DINP is considered the more toxic of the two because effects are observed at lower levels of exposure in rodent models. For DIDP, EPA determined that the evidence is not strong enough to conclude that it can cause cancer in people.
  • How does DINP/DIDP work?
  • Absorption, distribution, metabolism, and excretion studies conducted in rats show that after oral administration, the absorption of DINP/DIDP via gastrointestinal (GI) tract is very rapid, while their dermal absorption appears to be very minimal (<5%) [ 16, 24 ]. Once absorbed, DINP/DIDP predominantly distributes in blood, liver, and kidney.
  • Is DIDP a good alternative to DEHP?
  • Therefore, DIDP appears to be an alternative to most of the uses of DEHP (EU, 2008; www.dehp-facts.com), with the main exception for use in medical devices (European Council for Plasticisers and Intermediates (ECPI), ECPI, 2007). The main applications of DIDP are similar to those of DINP. DIDP is primarily used to soften PVC.
  • Where does DINP/DIDP metabolize?
  • Once absorbed, DINP/DIDP predominantly distributes in blood, liver, and kidney. Initial ester hydrolysis of DINP/DIDP to their corresponding monoesters (MINP/MIDP) appears to happen in the GI tract; further oxidation of MINP/MIDP, to respective secondary metabolites (e.g., MHINP, and MOINP/MHIDP, and MOIDP), takes place in the liver [ 24 ].

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