Alternative plasticizer-DOTP Venezuela

  • Alternative plasticizer-DOTP Venezuela
  • Alternative plasticizer-DOTP Venezuela
  • Alternative plasticizer-DOTP Venezuela
  • Can plasticizers be used as ortho-phthalates?
  • Several plasticizers are identified and discussed in the paper. All may be used as plasticizers, but only some are considered alternatives to general purpose ortho-phthalates such as DEHP and DINP, while the others are specialty plasticizers with niche uses.
  • Where can I find toxicological data for alternative plasticizers?
  • For all selected alternative plasticizers, toxicological information is available to a certain extent. Since these substances are produced in high volumes, toxicological data are required in the EU and could be found in the ECHA database for registered substances (ECHA, 2014b).
  • Are there alternative plasticizers?
  • There are a considerable number of alternative plasticizers in employment, without any toxicological data available (dibutyl adipate, diethylene glycol dibenzoate, and bis-2-ethylhexyl sebacate, to name a few).
  • What are The DNEL values of alternative plasticizers?
  • These values were derived from a no observed adverse effect concentration (NOAEC) or no observed adverse effect level (NOAEL), divided by an assessment factor. Most long-term DNELs of alternative plasticizers are relatively high compared to DEHP (one of the most toxic phthalate plasticizers).
  • Do alternative plasticizers metabolize phthalates and DINCH?
  • For instance, the human metabolism of phthalates and DINCH is well known. Therefore, exposure to these substances can be well assessed by measuring relevant metabolites in human matrices like blood or urine. Unfortunately, this has not been done for all relevant alternative plasticizers.
  • Are alternative plasticizers phthalate or phosphate esters?
  • Additionally, some substances are not exclusively being used as plasticizers. For example, phosphate esters have also been widely used as flame retardants (Marklund et al., 2003, Wei et al., 2015). In this work, we consider the term “alternative plasticizer” as a synonym for non-phthalate plasticizers.

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