Alternative plasticizer-GYC TOTM Germany

  • Alternative plasticizer-GYC TOTM Germany
  • Alternative plasticizer-GYC TOTM Germany
  • Alternative plasticizer-GYC TOTM Germany
  • Which plasticizer is present in Plasticized PVC tubings?
  • The majority plasticizer present in the PVC and PVC coextruded with PE, PU and SEBS was TOTM. As shown in Table 5, TOTM was quantified in the PVC tubings and coextruded PVC and its migration was estimated. Percentages of TOTM in plasticized PVC tubings were not statistically different from those in the external PVC layer of coextruded tubings.
  • Are there alternative plasticizers?
  • “There are a number of alternative plasticizers on the market. While Teknor Apex is best known as a manufacturer of medical-grade PVC compounds, we also produce some of these plasticizers,” notes Galland.
  • What is the difference between DOTP & TOTM plasticizers?
  • Purity. If processed in truly dedicated equipment, DOTP can be produced nearly free of DEHP contamination. DOTP plasticizer producers specify a DEHP content of less than 50 parts per million, but almost all shipments contain significantly less than that. By contrast, TOTM can contain as much as 2,000 ppm of DEHP and is never free of it.
  • Can alternative plasticizers migrate from the PVC matrix?
  • Alternative plasticizers like Diisononyl Phtalate (DINP), Di- (2-Ethylhexyl) Phtalate (DEHT), 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) or Tris (2-Ethylhexyl) trimellitate (TOTM) were then used in the manufacturing of medical devices 18, yet all those alternatives plasticizers can potentially migrate from the PVC matrix.
  • Is TOTM a good plasticizer for crystalloid infusion?
  • Several studies confirmed that TOTM migration is lower compared to DEHP (up to 200-fold), to DEHA (up to 100-fold) and DEHT, making it a more suitable choice as plasticizer (Panneel et al., 2021). Indeed, TOTM was virtually absent in all crystalloid samples despite being the main plasticizer in all PMD used for crystalloid infusion.
  • Are alternative plasticizers safe for flexible PVC medical compounds?
  • While phthalate esters such as DEHP are the most widely used plasticizers for flexible PVC medical compounds and have been for 50 years, issues concerning their possible effects on human health have caused some device manufacturers to consider compounds containing alternative plasticizers. Sometimes the pressure to do so is considerable.

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