DBP dibutyl phthalate-Registration Dossier Korea

  • DBP dibutyl phthalate-Registration Dossier Korea
  • DBP dibutyl phthalate-Registration Dossier Korea
  • DBP dibutyl phthalate-Registration Dossier Korea
  • How are dialkyl phthalates metabolised?
  • The shorter-chain length dialkyl phthalates (e.g. DBP) are predominantly metabolised by ester hydrolysis to the simple monoester phthalates, which are excreted in urine, usually after glucuronidation.
  • What is the abbreviation for benzyl butyl phthalate?
  • Abbreviations: BBP, benzyl butyl phthalate; DBP, dibutyl phthalate; DEHP, di (2-ethylhexyl)phthalate; EU, European Union; MFDS, Ministry of Food and Drug Safety; N.C., not calculated; SCCS, Scientific Committee on Consumer Safety.
  • Are phthalates banned in Korea?
  • Currently, some types of phthalates, including BBP, DBP, and DEHP in cosmetics are banned in Europe and Korea (EC, 2009; MFDS, 2017a); however, BBP, DBP, and DEHP are regulated within 100 ppm total or per substance as unintentional contaminants in Korea (MFDS, 2017a).
  • Does DIBP affect phthalate exposure assessment?
  • Given its high potency relative to DEHP as the index substance, inclusion of DIBP can make a major impact on the outcome of an exposure assessment to a group of phthalates and on the risk characterisation – see for example Appendix C – Considerations on DIBP.
  • Are DBP phthalates the same as BBP?
  • While the three phthalates DBP, DEHP and BBP seemed to act on the same target organ (the testis), the profile of their effects at the hormonal and cellular level was not identical and their individual modes of action (MoA) had yet to be demonstrated. Moreover, the two others, DIDP and DINP, primarily affect the liver rather than the testis.
  • Is DIDP a phthalate?
  • Furthermore, ECHA (2013) noted: ‘DIDP seems to have a different toxicological spectrum and/or potency regarding reproductive toxicity than several other phthalates, such as DINP, DEHP and DBP which potentially cause androgen deficiency during male development.

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