Di-n-butyl Phthalate (DBP) Sri Lanka

  • Di-n-butyl Phthalate (DBP) Sri Lanka
  • Di-n-butyl Phthalate (DBP) Sri Lanka
  • Di-n-butyl Phthalate (DBP) Sri Lanka
  • What is di-n-butyl phthalate (DBP)?
  • Di-n-butyl phthalate (DBP), a well-known EDC, is widely used in industrial productions. The use or disposal of plastics leads to ubiquitous exposure to DBP, which adversely affects male reproductive health 2.
  • Does di n -butyl phthalate have a systemic effect?
  • As a result of early findings on testicular effects of di- n -butyl phthalate, most studies have tended to concentrate mainly on developmental and reproductive effects. A few studies provide data on systemic effects, but since these appear to be minor, research in this area has not been extensive.
  • What is di n -butyl phthalate?
  • Di- n -butyl phthalate and its primary metabolite, mono- n -butyl phthalate, have been detected in placental and embryonic tissues of treated pregnant rats ( Saillenfait et al. 1998 ), with mono- n -butyl phthalate accounting for 50–95% of the total amount recovered.
  • How is di n -butyl phthalate distributed in humans?
  • There are no data on the distribution of di- n -butyl phthalate in humans. Animal data suggest that following inhalation, oral, or dermal exposure, di- n -butyl phthalate is widely distributed throughout the body and does not accumulate in the body. There are no data on transplacental transfer or transfer via maternal milk.
  • Does di n -butyl phthalate have mutagenic potential?
  • A limited number of in vitro tests for genotoxicity suggest that di- n -butyl phthalate may have weak genotoxic potential. No in vivo studies have been conducted. In vivo genotoxicity studies are needed to determine whether di- n -butyl phthalate has mutagenic potential and, if so, what the possible mechanism of genotoxicity might be.
  • What is a pharmacokinetic model for di n -butyl phthalate?
  • The model is designed to simulate the pharmacokinetics of di- n -butyl phthalate and its metabolite, mono- n -butyl phthalate, when exposure is by the oral route.

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