Diisononyl Phthalate (DINP)-Proposition 65 Warnings Website Iran

  • Diisononyl Phthalate (DINP)-Proposition 65 Warnings Website Iran
  • Diisononyl Phthalate (DINP)-Proposition 65 Warnings Website Iran
  • Diisononyl Phthalate (DINP)-Proposition 65 Warnings Website Iran
  • When did EPA request a risk evaluation for Diisodecyl phthalate (DIDP)?
  • EPA received and granted manufacturer requests for risk evaluations of DINP and for diisodecyl phthalate (DIDP) in 2019. EPA released the draft risk evaluation for DIDP in May 2024 and requested peer review on the DINP human health hazard assessment at that time.
  • Does DINP cause phthalate syndrome?
  • However, DINP does have the potential to cause phthalate syndrome. Therefore, EPA is including DINP in its cumulative risk assessment along with five other phthalate chemicals that have the potential to cause phthalate syndrome, while DIDP is excluded from the cumulative risk assessment.
  • How does Di-isononyl phthalate affect the gastrointestinal tract?
  • Di-isononyl phthalate (DiNP), a common plasticizer used in polyvinyl chloride products, exhibits endocrine-disrupting capabilities. It is also toxic to the brain, reproductive system, liver, and kidney. However, little is known about how DiNP impacts the gastrointestinal tract (GIT).
  • Does diisononyl phthalate cause hepatic and renal tissue injury?
  • Ma, P. et al. Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin. Food Chem. Toxicol. 68, 247–256 (2014). Byers, S. L. et al. Mouse estrous cycle identification tool and images. PLoS ONE 7 (4), e35538 (2012).
  • What are the DINP doses used in this study?
  • The DiNP doses used in this study included the following: 0, 0.02, 0.2, 2, 20, and 200 mg/kg. The highest dose (200 mg/kg DiNP stock solution) was made by diluting concentrated DiNP (as purchased from Sigma-Aldrich, CAS Number 28553-12-0) in corn oil.
  • Does Di-isononyl phthalate affect morphology and endocrine function?
  • Chiu, K., Bashir, S.T., Nowak, R.A. et al. Subacute exposure to di-isononyl phthalate alters the morphology, endocrine function, and immune system in the colon of adult female mice.

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