DINP-DIDP: 5. What health effects can DIDP and DINP cause in laboratory animals

5. What health effects can DIDP and DINP cause

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:28553-12-0
Other Names:Di-isononyl phthalate
MF:C26H42O4
EINECS No.:271-090-9
Purity:99%, 99%
Type:DINP
Usage:Plastic Auxiliary Agents, Plasiticizer
MOQ:1000KG
Package:25kg/drum
Certification:ISO9001

DIDP. Effects assessment. Toxicokinetics, metabolism and distribution. The data available on toxicokinetic suggest that, via gastro-intestinal tract (GIT), absorption of DIDP decreases as

DINP . Although DIDP and DINP have similar uses, EPA identified several important differences in the potential effects on human health posed by DIDP and DINP. Both

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Toxicity Review for Diisodecyl Phthalate (DIDP) CPSC

Classification:Chemical Auxiliary Agent
CAS No.:68515-48-0
Other Names:DINP
MF:C26H42O4, C26H42O4
EINECS No.:249-079-5
Purity:99.6%
Type:PVC resin plasticizer
Usage:Plastic Auxiliary Agents, Rubber Auxiliary Agents
MOQ:1000KG
Package:25kg/drum
Shelf life:2 Years

In a 21-day feeding study, Fischer 344 rats were fed 0, 0.3, 1.2, and 2.5% DIDP (300, 1000 or 2000 mg/kg/day as calculated by NICNAS, 2008) (BIBRA, 1986). There was a statistically

– Case studies: DBP, DEHP, DINP, DIDP Conclusion DINP and DIDP are not endocrine disruptors. • "An endocrine disrupter is an exogenous substance that causes adverse health

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Phthalates and Their Impacts on Human Health PMC

Classification:Chemical Auxiliary Agent
CAS No.:68515-48-0
MF:C26H42O4, C26H42O4
EINECS No.:249-079-5
Purity:99.5%Min
Type:Adsorbent
Usage:Coating Auxiliary Agents, Leather Auxiliary Agents, Paper Chemicals, Petroleum Additives, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Surfactants, Textile Auxiliary Agents, Water Treatment Chemicals
MOQ:1000KG
Package:25kg/drum
Shelf life:2 Years

Since 2007, Europe banned DEHP, DBP, and BBP in all PVC and other plasticized materials in all toys and childcare articles, and DiNP, DiDP, and di-n-octyl phthalate (DnOP) for those

5. What health effects can DIDP and DINP cause in laboratory animals? If DIDP or DINP are swallowed, about 50% of it is absorbed from the gut into the blood. Absorption through the

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Selecting Adequate Exposure Biomarkers of Diisononyl

Classification:Chemical Auxiliary Agent
CAS No.:68515-48-0
MF:C26H42O4
EINECS No.:249-079-5
Purity:99.5%Min
Type:Adsorbent
Usage:Coating Auxiliary Agents, Electronics Chemicals, Leather Auxiliary Agents, Paper Chemicals, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Surfactants, Textile Auxiliary Agents
MOQ:200kgs
Package:200kgs/battle
Model Number:DINP

health effects, particularly among the young. Data for several phthalates are available, but exposure information for high molecular weight phthalates, including DINP and DIDP, is

Exposure to DINP/DIDP. 95. th % DINP exposure (Waterman et al., 1999); Testis histopathology reported in a small number of animals (Gray et al., 2000) 10 Integrated data

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Human Biological Monitoring of Diisononyl Phthalate

Classification:Chemical Auxiliary Agent
CAS No.:68515-48-0
Other Names:Plasticizer DINP
MF:C26H42O4 Diisononyl Phthalate
EINECS No.:249-079-5
Purity:99%
Type:New Type Environment DINP Plasticizer
Usage:Plastic Auxiliary Agents
MOQ:1000KG
Package:25kg/drum
Function:PVC Plasticizer

However, the estimated mean total daily intake values for DEHP, DINP, and DIDP were 4.5, 2.4, and 0.3 μg/kg body weight/day, respectively, suggesting that the exposure to

What health effects can DIDP and DINP cause in laboratory animals? DIDP and DINP are absorbed well when swallowed or breathed in, but are poorly absorbed through the skin. 6.1 When human exposures are

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What is the absorption of DINP/DIDP?
Excretion of DINP and DIDP Absorption, distribution, metabolism, and excretion studies conducted in rats show that after oral administration, the absorption of DINP/DIDP via gastrointestinal (GI) tract is very rapid, while their dermal absorption appears to be very minimal (<5%) [ 16, 24 ].
Is DIDP a contaminant?
A single dose of DIDP or DINP which is breathed in, swallowed (for example as a contaminant in food) or absorbed through the skin has a low toxicity. DIDP and DINP are not irritant to skin, eyes or respiratory system, nor do they cause skin or respiratory sensitization.
Does DIDP cause cancer?
DIDP and DINP have not been shown to cause damage to the inherited genetic material in cells (chromosomes and DNA) as shown by several laboratory tests. DIDP was found to cause liver cancer through a mechanism that is specific to rodents and does not affect humans.
Are DIDP & DINP irritant?
DIDP and DINP are not irritant to skin, eyes or respiratory system, nor do they cause skin or respiratory sensitization. In rodents and dogs, toxicity to the liver is the main result of repeated oral exposure to DIDP or DINP.
What is the difference between DIDP and DINP?
Both DIDP and DINP can cause developmental toxicity and liver damage, but DINP is considered the more toxic of the two because effects are observed at lower levels of exposure in rodent models. For DIDP, EPA determined that the evidence is not strong enough to conclude that it can cause cancer in people.
How does DINP/DIDP work?
Absorption, distribution, metabolism, and excretion studies conducted in rats show that after oral administration, the absorption of DINP/DIDP via gastrointestinal (GI) tract is very rapid, while their dermal absorption appears to be very minimal (<5%) [ 16, 24 ]. Once absorbed, DINP/DIDP predominantly distributes in blood, liver, and kidney.