dop-1 (gene)-WormBase : Nematode Information Resource Indonesia

  • dop-1 (gene)-WormBase : Nematode Information Resource Indonesia
  • dop-1 (gene)-WormBase : Nematode Information Resource Indonesia
  • dop-1 (gene)-WormBase : Nematode Information Resource Indonesia
  • Is dop-1 a biogenic amine receptor?
  • As putative dopamine receptor sequences, Dop-1 was highly identical degree with histamine receptor-like sequences confirmed by pharmacology experiment 44 ], and A. californica (Dop) (Fig. 4 ), implying that these sequences were perhaps related to the prototype biogenic amine receptors such as the dopamine receptor.
  • Is C elegans dop4 a D1-like receptor?
  • The C. elegans Dop4 identified as D1-like receptor unique to invertebrates 22 is located at the out-group of invertebrate Dop1R2 branch, suggesting that Dop1R2 probably as INDR split from its ancestor before the emergence of nematodes.
  • How do Dop1 and dop2 function?
  • Like the mammalian D1-like receptors, DOP1 (Dop1R1) and DOP2 (Dop1R2) upregulate cAMP levels when stimulated with dopamine and therefore function like D1-like receptors. Their sequence structure also has relatively short third cytoplasmic loops and relatively long carboxyl tails.
  • Which insects have dopamine receptor genes?
  • Since the 1990s, a number of dopamine receptor genes have been identified and isolated from insects including Drosophila melanogaster 14, 18, 21, Apis mellifera 20, Periplaneta Americana 19, Ctenocephalides felis 15, Papilio xuthus 17, Tribolium castaneum 23, Chilo suppressalis 24, 25 and Bombyx mori 26, 27.
  • Are dop-2 mutants more sensitive to exogenous dopamine than wild-type animals?
  • The response of dop-2 mutants to exogenous dopamine was similar to that of wild-type animals, and dop-1 mutants were, if anything, slightly more sensitive to exogenous dopamine than wild-type animals (Fig. 3b). dop-3 mutants, however, were resistant to the paralytic effects of exogenous dopamine.
  • Which nematode is a good model for pharmacological research?
  • The nematode C. elegans is a well-standardized model for pharmacological research, both due to its easy of obtaining, maintenance and manipulation.

Recommended hot-selling products