Evaluation of the Direct Toxicity of Trioctyltrimellitate (TOTM) Morocco

Evaluation of the Direct Toxicity of Trioctyltrimellitate

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:3319-31-1
Other Names:Heat resistant Plasticizer TOTM
MF:C6H3(COOC8H17)3
EINECS No.:222-020-0
Purity:100%
Type:plasticizer
Usage:Coating Auxiliary Agents, Plastic Auxiliary Agents, wires, cabler, PVC Plastisols,Leather Cloth
Package:25kg/drum
Color:Colorless Transparent
Shape:Liquid
Melting point( ℃):46°C‌

Dec 1, 2004To evaluate the possible toxic liver risk resulting from exposure to DEHP and TOTM, isolated rat hepatocytes were incubated with either DEHP, TOTM, MEHP or their

Plasticizers are added to polyvinyl chloride (PVC) to confer flexibility to the polymer. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used of them. However, due to its non

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Evaluation of the direct toxicity of trioctyltrimellitate (TOTM),

Classification:Chemical Auxiliary Agent
CAS No.:3319-31-1
Other Names:Heat resistant Plasticizer TOTM
MF:C6H3(COOC8H17)3
EINECS No.:222-020-0
Purity:99%min
Type:plasticizer
Usage:Coating Auxiliary Agents, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Textile Auxiliary Agents, Water Treatment Chemicals
Package:200kgs/battle
Product Name:TOTM Trioctyl trimellitate
Color:Colorless Transparent
Acid value(mg KOH/g)≤0.20mgKOH/g

Evaluation of the direct toxicity of trioctyltrimellitate (TOTM), di(2-ethylhexyl) phthalate (DEHP) and their hydrolysis products on isolated rat hepatocytes

Trioctyltrimellitate (TOTM) is trimellitate plasticizers which exhibits a low potential of toxicity due to its relative higher molecular weight and bulky side chains. Kambia K, Dine T, Gressier B, Dupin-Spriet T, Luyckx M, et al. (2004)

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Evaluation of the direct toxicity of trioctyltrimellitate (TOTM),

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:3319-31-1
Other Names:Heat resistant Plasticizer TOTM
MF:C6H3(COOC8H17)3
EINECS No.:222-020-0
Purity:100%
Type:plasticizer
Usage:Plastic Auxiliary Agents, Rubber Auxiliary Agents
Package:200kgs/battle
Color:Colorless Transparent
Acid value(mg KOH/g)≤0.20mgKOH/g

Nov 1, 2004This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice

Tris (2-ethylhexyl) trimellitate (TOTM), a trimellitate ester, is commonly used for medical devices as an alternative plasticizer to replacing DEHP (an ester of phthalic acid;

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Evaluation of the Direct Toxicity of Trioctyltrimellitate

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:3319-31-1
Other Names:PVC plasticizer
MF:C6H3(COOC8H17)3
EINECS No.:222-020-0
Purity:99.5
Type:trioctyl trimellitate plasticizer TOTM
Usage:Leather Auxiliary Agents, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Textile Auxiliary Agents
Package:25kg/drum
Color:Colorless Transparent
Acid value(mg KOH/g)≤0.20mgKOH/g

Nov 1, 2004Because of the suspected toxicity of DEHP, an alternative plasticizer, trioctyltrimellitate (TOTM) has aroused increasing interest. The aim of this study was to

DEHP induced serious changes on liver; most of these changes were irreversible and recommended to use safely as an alternative plasticizer. Di (2-ethylhexyl) phthalate (DEHP)

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CPSC Staff Statement on University of Cincinnati Report

Classification:Chemical Auxiliary Agent
CAS No.:3319-31-1
Other Names:PVC plasticizer
MF:C6H3(COOC8H17)3
EINECS No.:222-020-0
Purity:99.5
Type:trioctyl trimellitate plasticizer TOTM
Usage:Petroleum Additives, Pressure Swing Adsorption
Package:25kg/drum
Color:Colorless Transparent
Melting point( ℃):46°C‌

TOXICITY REVIEW FOR . TRIOCTYLTRIMELLITATE (TOTM) Contract No. CPSC-D-17-0001 . Task Order No. 003 . Prepared by: Risk Science Center . Department of

).It has been reported that TOTM shows weaker hepatotoxicity than DEHP but exerts significant estrogenic activity

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Are rat hepatocytes toxic if exposed to DEHP and Totm?
To evaluate the possible toxic liver risk resulting from exposure to DEHP and TOTM, isolated rat hepatocytes were incubated with either DEHP, TOTM, MEHP or their common metabolite (2-EH) for 3 hours. Cell viability was periodically estimated thanks to trypan blue tests (15 - 180 min).
Does TOTM cause toxicity in general?
In the studies conducted, TOTM caused only minimal signs of toxicity. The primary effects noted in the systemic toxicity studies were peroxisome proliferation and related effects in the liver (CMA, 1986, 1987; Hodgson, 1987). Males were more sensitive than females to peroxisome proliferation. However, the passage does not directly answer whether TOTM causes toxicity in all cases or under all conditions. It only mentions the findings from specific studies.
Is TOTM a peroxisome proliferator?
According to the report, TOTM appears to be a peroxisome proliferator. Despite producing effects similar to DEHP in a 28-day oral rat study (CMA, 1986; Hodgson, 1987), TOTM was much less potent.
Is TOTM toxic for albino white rabbits?
In a GLP-compliant study, there were no signs of toxicity, body weight changes, or death in a group of 3 male and 3 female New Zealand albino white rabbits when 2.0 mL/kg of TOTM (1970 mg/kg, based on a density of 0.985 g/cm3) was applied to their abraded skin.
How toxic is Kodak TOTM when heated?
Eastman Kodak Co. reported much higher toxicity for Kodak TOTM in a study where the solution was heated to 180oC (U.S. EPA, undated; ECHA, 2018). In contrast, the low toxicity with the TOTM aerosol is not mentioned in this context.
What is occupational exposure to TOTM?
Occupational exposure to TOTM (Tetrachloro-1,3-butadiene) is primarily through dermal contact and breathing mists in the plastics industry (HSDB, 2018). However, it is produced and used in closed systems, and occupational exposure time is reported to be very short and limited to sampling and maintenance at the production facilities (SCENIHR, 2016).