good stability The Facts about DEHP/DOP

  • good stability The Facts about DEHP/DOP
  • good stability The Facts about DEHP/DOP
  • good stability The Facts about DEHP/DOP
  • How much DEHP is in plastic?
  • Plastics may contain from 1 to 40% DEHP by weight. An estimated 90% of DEHP is used as a plasticizer for polyvinyl chloride (PVC) polymers ( Toxics Use Reduction Institute, 2005 ). In the EU, 95% of DEHP is used as a plasticizer in polymer products ( European Commission, 2008 ).
  • Why does DEHP form more octanol in water?
  • The probable explanation is that DEHP readily forms more or less colloidal dispersions in water. Natural constituents in water may influence the solubility. A non-colloidal solubility of 0.003 mg/L is chosen for the Risk assessment. The Henry´s law constant for DEHP is 4.43 Pa m 3 /mol. The octanol-water partition coefficient, log Kow, is 7.5.
  • Is DEHP soluble in water?
  • "Bis- (2-Ethylhexyl) Phthalate, DEHP), Summary Risk Assessment report" , 2008. p.3-4. The same information on DEHP is a colourless oily liquid that is soluble in fat and not very soluble in water. It is not very volatile so does not vaporise readily into the atmosphere.
  • What is DEHP used for?
  • Industrial and commercial uses of DEHP include resilient flooring, wall covering, roofing, aluminium foil coating/laminating, paper coating, extrudable moulds and profiles, electronic component parts, and wire and cable coating and jacketing. Medical devices comprise approximately 25% of total manufacturing use of DEHP in the USA.
  • How is DEHP metabolized?
  • Upon ingestion, DEHP is rapidly metabolized to MEHP by pancreatic lipases in the lumen of the gut in both rodents and humans, before being further converted into oxidative metabolites and glucuronidated for excretion in the urine and faeces. The review by Silva et al., (2006) shows the metabolic schema for humans and rodents ( Fig. 4.1 ).
  • Does DEHP increase CYP3A activity?
  • In human primary hepatocytes and cancer cell lines, some studies have shown that DEHP can increase activity and/or expression of the CYP3A, CYP2B and CYP1A family of enzymes.

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