high performance Bis(2-propylheptyl) Phthalate (DPHP)

  • high performance Bis(2-propylheptyl) Phthalate (DPHP)
  • high performance Bis(2-propylheptyl) Phthalate (DPHP)
  • high performance Bis(2-propylheptyl) Phthalate (DPHP)
  • Is DPHP a phthalate?
  • Therefore, these studies were evaluated based on a published review and data compilation (Bhat et al., 2014; ECHA, 2018b). DPHP is an ortho phthalate with a backbone of C7 branched alcohol with a propyl side chain. DPHP is currently considered to belong to the High Molecular Weight Phthalate Esters (HMWPE) group.
  • What is DPHP used for?
  • DPHP is registered under REACH (Regulation (EC) No. 1907/2006) and intended as a plasticizer in polyvinyl chloride (PVC) and vinyl chloride (VC) applications. In particular, DPHP is used in cables, carpet backing, roofing membranes and car interiors due to its low volatility and resistance to high temperatures.
  • Does DPHP cause phthalate syndrome?
  • At lower doses, this syndrome is manifested as decreased anogenital distance (AGD) and changes in nipple/areolae retention, while effects at higher doses include malformations of the male reproductive tract, external genitalia (hypospadias), and cryptorchidism (undescended testes). There was no evidence of phthalate syndrome from exposure to DPHP.
  • How are phthalates and DPHP monitored?
  • Therefore, the biological monitoring of phthalates and DPHP are commonly performed by measuring the corresponding metabolites instead of the original chemical form.
  • What group does DPHP belong to?
  • DPHP is currently considered to belong to the High Molecular Weight Phthalate Esters (HMWPE) group. DPHP is a specific isomer of di-isodecyl phthalate (DIDP) (NICNAS, 2003). The identity and physicochemical properties of DPHP can be seen in Tables 2.1 and 2.2 (NICNAS, 2003).
  • Is DPHP a biotransformation product?
  • A biotransformation product of DPHP, mono- (2-propyl-7-dihydroxy-heptyl) phthalate, was suggested as a DPHP exposure marker for general human exposure assessments. Phthalates are widely used in industry, plastics, construction materials, and personal care products, so humans are frequently exposed to phthalate compounds.

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