high performance DINP-American Chemistry

  • high performance DINP-American Chemistry
  • high performance DINP-American Chemistry
  • high performance DINP-American Chemistry
  • Can EPA conduct a risk evaluation of DIDP & DINP?
  • The risk evaluations of DIDP and DINP are the first two manufacturer-requested risk evaluations EPA has conducted. Under TSCA, manufacturers can request that EPA conduct risk evaluations on chemicals they manufacture. EPA received and granted manufacturer requests for risk evaluations of DIDP and DINP in 2019. DIDP
  • Does DINP cause phthalate syndrome?
  • However, DINP does have the potential to cause phthalate syndrome. Therefore, EPA is including DINP in its cumulative risk assessment along with five other phthalate chemicals that have the potential to cause phthalate syndrome, while DIDP is excluded from the cumulative risk assessment.
  • What is the difference between DIDP and DINP?
  • Both DIDP and DINP can cause developmental toxicity and liver damage, but DINP is considered the more toxic of the two because effects are observed at lower levels of exposure in rodent models. For DIDP, EPA determined that the evidence is not strong enough to conclude that it can cause cancer in people.
  • How many uses contribute to the unreasonable risk of DINP?
  • In the draft risk evaluation, EPA preliminarily determined that two industrial uses and one consumer use significantly contribute to the unreasonable risk of DINP out of the 45 uses evaluated.
  • Does EPA need a peer review of the DINP human health hazard assessment?
  • EPA released the draft risk evaluation for DIDP in May 2024 and requested peer review on the DINP human health hazard assessment at that time. The Science Advisory Committee on Chemicals (SACC) is currently engaged in peer review of these documents.
  • Are DIDP and DINP TSCA safe?
  • There are other uses of DIDP and DINP that are generally excluded from TSCA, such as personal care products, cosmetics, and food contact materials, and EPA did not evaluate risk associated with these uses. The risk evaluations of DIDP and DINP are the first two manufacturer-requested risk evaluations EPA has conducted.

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