Human exposure hazard and risk of alternative plasticizers Vietnam

  • Human exposure hazard and risk of alternative plasticizers Vietnam
  • Human exposure hazard and risk of alternative plasticizers Vietnam
  • Human exposure hazard and risk of alternative plasticizers Vietnam
  • Are alternative plasticizers safe?
  • According to current knowledge, the use of alternative plasticizers seems to be of low risk for humans as calculated risk ratios were mostly well below 1. Also, none of the selected alternatives are PBT or vPvB substances although TEHPA could be considered persistent and TCP toxic.
  • Do plasticizers have a long-term toxicity?
  • However, for plasticizers in particular, constant production and emission can lead to continuous exposure and pseudo-persistence. Attention should be paid to TEHPA, ESBO and TCP due to persistence, high exposure (to infants) and toxicity, respectively.
  • Are alternative phthalate plasticizers toxic?
  • Most long-term DNELs of alternative plasticizers are relatively high compared to DEHP (one of the most toxic phthalate plasticizers). Also other phthalates (DINP, DIDP, DPHP) were less toxic than DEHP, having higher DNELs. For DBA, COMGHA, DOS and DBS no hazard was identified due to the extremely low toxicities measured.
  • Do alternative plasticizers metabolize phthalates and DINCH?
  • For instance, the human metabolism of phthalates and DINCH is well known. Therefore, exposure to these substances can be well assessed by measuring relevant metabolites in human matrices like blood or urine. Unfortunately, this has not been done for all relevant alternative plasticizers.
  • Do plasticizers cause human exposure?
  • Evidence for human exposure such as biomonitoring data are rare and exist only for DINCH and DEHT. In this section, we focus mainly on indoor exposure. However, dietary exposure was considered as well because plasticizers might partition into food or water from packaging or during food processing. Table 3.
  • Where can I find toxicological data for alternative plasticizers?
  • For all selected alternative plasticizers, toxicological information is available to a certain extent. Since these substances are produced in high volumes, toxicological data are required in the EU and could be found in the ECHA database for registered substances (ECHA, 2014b).

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