In vitro cytotoxic effects of DEHP-alternative plasticizers Indonesia

In vitro cytotoxic effects of DEHP-alternative plasticizers

Classification:Chemical Auxiliary Agent
Other Names:Plasticizer
Purity:99.6%, 99.6%
Type:Plasticizer
Usage:Coating Auxiliary Agents, Leather Auxiliary Agents, Plastic Auxiliary Agents, Rubber Auxiliary Agents
MOQ:200kgs
Package:200kgs/battle
Shape:Powder
Payment:T/T
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All plasticizers induce an action on cell proliferation at 0.1 mg/ml. • DEHP, ATBC and DINCH are considered as potentially toxic in the standard EN 10993-5.. All plasticizers

In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line. Author links open overlay panel Teuta Eljezi a b 1, Pierre Pinta

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In vitro cytotoxic effects of DEHP-alternative plasticizers

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
Other Names:Plasticizer
Purity:99.5
Type:Plastic Auxiliary Agents
Usage:Plastic Auxiliary Agents, Textile Auxiliary Agents
MOQ:1000KG
Package:25kg/drum
Advantage:Stable

DOI: 10.1016/j.chemosphere.2017.01.026 Corpus ID: 24378027; In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line.

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In vitro cytotoxic effects of secondary metabolites of DEHP

Classification:Chemical Auxiliary Agent
Other Names:Plasticizer
Purity:99.99, 99%
Type:Plasticizer Colorless Oily Liquid for pvc and rubber
Usage:Leather Auxiliary Agents, Plastic Auxiliary Agents, Plasticizer
MOQ:1000KG
Package:25kg/drum
Payment:T/T
Certificate::COA

The most famous plasticizer is DEHP, whose use in medical devices has been contested by the European authorities since 2008. Several alternative plasticizers are being considered to

Interestingly, mono-(2-ethylhexyl) phthalate (MEHP, a DEHP metabolite) and several DINCH and DEHTP metabolites presented more cytotoxic dose-response effects than

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In vitro cytotoxic effects of DEHP-alternative plasticizers

Classification:Chemical Auxiliary Agent
Other Names:Plasticizer
Purity:99.5, ≥99.5
Type:Plasticizer, Dioctyl Phthalate
Usage:Leather Auxiliary Agents, Paper Chemicals, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Textile Auxiliary Agents
MOQ:25kg/bag
Package:200kg/drum
Storage:Dry Place

42 In vivo and in vitro research links DEHP or its metabolites to a range of adverse effects in the liver, reproductive tract, kidneys, lungs, and heart; in addition, developing

Our study focuses on the in vitro cytotoxicity of two alternative plasticizers (DINCH and DINP) contained in certain medical devices.They are likely to migrate and be transformed

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In vitro cytotoxic effects of secondary metabolites of

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
Other Names:Plasticizer
Purity:99.5, ≥99.5
Type:Plastic Auxiliary, Plasticizer For Pvc
Usage:Coating Auxiliary Agents, Leather Auxiliary Agents, Paper Chemicals, Plastic Auxiliary Agents, Rubber Auxiliary Agents
MOQ:25kg/bag
Package:200kg/drum
Storage:Dry Place

1 In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line Teuta Eljezi,a,b,1 Pierre Pinta,c,1 Fabien Nativelc

In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line

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Are DEHP-alternative plasticizers cytotoxic?
In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clinical situations.
Are alternative plasticizers cytotoxic in vivo?
Objectives: Our study focuses on the in vitro cytotoxicity of two alternative plasticizers (DINCH and DINP) contained in certain medical devices. They are likely to migrate and be transformed in vivo into the primary and secondary metabolites by a metabolism similar to that of DEHP.
Is Deha cytotoxic?
DEHA showed no cytotoxicity, but its corresponding monoester ( MEHA) produced a cytotoxic effect at 0.05 mg/ml. In clinical situations, medical devices can release plasticizers, which can come into contact with patients. In vivo, the plasticizers are quickly transformed into primary metabolites.
Are plasticizers toxic?
All plasticizers induce an action on cell proliferation at 0.1 mg/ml. DEHP, ATBC and DINCH are considered as potentially toxic in the standard EN 10993-5. All plasticizers primaries metabolites cause a decrease in cell viability except MOTM. MINCH causes a very high inhibition of cell proliferation.
Are plasticizers toxic to fibroblasts?
Concerning cytotoxicity of plasticizers, no effect was observed at 0.01 mg/mL. DEHP and DINCH caused a decrease in L929 cell proliferation from the concentration of 0.05 mg/mL, and their effect was massive at the highest concentration, with total cell death. DINCH was as toxic as DEHP for the L929 fibroblast cells.
Are plasticizers cytotoxic?
However, authors report difficulties applying the EN 10993-5 ( NF, 2009) standard for plasticizers: these substances are hydrophobic, and cannot be used as they are for direct contact in a culture medium. It is therefore necessary to use a solvent for these materials, which is itself non-cytotoxic toward the cells, to perform the tests.