melflex dotp dioctyl terephthalate Switzerland

  • melflex dotp dioctyl terephthalate Switzerland
  • melflex dotp dioctyl terephthalate Switzerland
  • melflex dotp dioctyl terephthalate Switzerland
  • What is di-octyl terephthalate (DOTP)?
  • Di-Octyl Terephthalate (DOTP) is a versatile and environmentally friendly plasticizer widely used in various industries. Its primary function is to enhance the flexibility, durability, and workability of polyvinyl chloride (PVC) products while offering several advantages over traditional phthalate-based plasticizers.
  • Why is di-octyl terephthalate important?
  • Overall, DOTP's versatility, performance, and environmental compatibility make it a valuable ingredient in modern polymer formulations across various sectors. Di-Octyl Terephthalate (DOTP) is a versatile and environmentally friendly plasticizer widely used in various industries.
  • Is terephthalic acid a surrogate for DBT?
  • The REACH registration file for DBT (ECHA, 2021a) appears to use read-across to terephthalic acid, dimethyl phthalate, or DOTP as surrogates; however, based on the available data for those substances, no health concerns were raised by US FDA. 3.2.3. Bis (2-ethylhexyl) cyclohexane-1,4-dicarboxylate (DEHCH) –CAS# 84731-70-4
  • Are physiological based pharmacokinetic models available for DOTP?
  • Recently, physiological based pharmacokinetic models (PBPK) were published for DINCH (McNally et al., 2019) and for two ortho-phthalates, DINP (Campbell et al., 2020) and di-propyheptyl phthalate (DPHP, McNally et al., 2021). We understand that a model for DOTP also is under development.
  • How much ASE & DOTP are in simulants for aqueous and low alcohol foods?
  • Migration of ASE, COMGHA, DINCH, DOTP, DEHCH, and TOTM in simulants for aqueous and low alcohol foods ranged from <0.02 to 0.165 mg/kg. Human biomonitoring data are available for DINCH, DOTP, DEHA, DINA, and TOTM, and indicate that total exposures from all sources are below regulatory thresholds.

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