Migrability of PVC plasticizers from medical devices into a
- Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
- Other Names:Plasticizer
- Purity:99.0%Min
- Type:Plastic Auxiliary Agents
- Usage:Rubber Auxiliary Agents
- MOQ:200kgs
- Package:200kgs/battle
- Application:PVC Plasticizer
- Item:T/T,L/C
Samples of the plasticized PVC tubings used for the experiments were 30 cm in length, with an internal diameter of 3 mm and an external diameter of 4.1 mm.They were cut
Indeed, it is difficult to choose a solvent based on the literature, as data available concern only extraction of a restricted number of plasticizers (DBP, DEHP, DEHT, and TOTM
Migrability of PVC plasticizers from medical devices into a
- Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
- Other Names:Plasticizer
- Purity:99.99, 99%
- Type:Adsorbent, plasticizer
- Usage:Plastic Auxiliary Agents, Textile Auxiliary Agents
- MOQ:25kg/bag
- Package:200kg/drum
- Storage:Dry Place
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Introduction PVC has been widely used in the field of medical devices (MD) to produce flexible tubings such as infusion sets, haemodialysis lines, or extracorporeal circulation tubes.
Migration of plasticizers from PVC medical devices:
- Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
- Other Names:Plasticizer
- Purity:99.5%min, 99.5%min
- Type:Oil drilling
- Usage:Coating Auxiliary Agents, Electronics Chemicals, Leather Auxiliary Agents, Paper Chemicals, Petroleum Additives, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Surfactants, Textile Auxiliary Agents, Water Treatment Chemicals
- MOQ:1000KG
- Package:25kg/drum
- Advantage:Stable
The manufacture of medical devices (MD), such as infusion or artificial nutrition tubings, from polyvinyl chloride (PVC) requires the incorporation of plasticizers, which are
Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g
Migration of plasticizers from PVC medical devices PubMed
- Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
- Other Names:Plasticizer
- Purity:99 %
- Type:Plastic Auxiliary Agents
- Usage:Leather Auxiliary Agents, Paper Chemicals, Petroleum Additives, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Textile Auxiliary Agents, Leather Auxiliary Agent,Plastic Auxiliary Agent,
- MOQ:25kg/bag
- Package:200kg/drum
- Advantage:Stable
- Payment:T/T
Alternatives to DEHP plasticizers are used in various PVC medical devices (MD) for infusion. As they are able to migrate from these MDs into infused solutions, they may come
Medical devices (MD) for infusion and artificial nutrition are essentially made of plasticized PVC.The plasticizers in the PVC matrix can leach out into the infused solutions and
Effects of flow rate on the migration of different plasticizers
- Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
- Other Names:Plasticizer
- Purity:99.0%Min
- Type:Liquid, plasticizer
- Usage:Coating Auxiliary Agents, Leather Auxiliary Agents, Paper Chemicals, Plastic Auxiliary Agents, Rubber Auxiliary Agents
- MOQ:25kg/bag
- Package:200kg/drum
- Shape:Powder
- Place of Origin::China
- Advantage:Stable
2018, PloS one. Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients.
For standard PVC sheets, standard PVC tubings, and PVC medical devices containing plasticizers, two methods were applied: direct dissolution in THF-d 8 or plasticizer extraction from PVC with CDCl
- Are PVC plasticizers harmful to patients?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evalu … Migrability of PVC plasticizers from medical devices into a simulant of infused solutions Int J Pharm.
- Are plasticizers in the PVC matrix a risk factor for patient exposure?
- The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs.
- Does the migration of plasticizers vary with the type of medical device?
- The results highlight that the migration of plasticizers varies greatly with the type of medical device.
- How many plasticizers are released during migration assays?
- Quantity of plasticizers released during migration assays from the 4 infusion sets tested (n = 3, mean +/- standard deviation). The quantity of plasticizers released into the simulant raises gradually during the infusion period, regardless the type of device and the plasticizer integrated into the PVC.
- Does flow rate affect migrability of plasticizers?
- The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated.
- How are plasticizers analyzed in PVC tubings?
- Chromatographic analyses of both the plasticizers in the PVC tubings after solvent extraction (before migration tests) and in the simulant after contact with the samples (specific migration) were performed according to the analytical method described by Bernard et al. (2015).
