Migrability of PVC plasticizers from medical devices into a Iran

  • Migrability of PVC plasticizers from medical devices into a Iran
  • Migrability of PVC plasticizers from medical devices into a Iran
  • Migrability of PVC plasticizers from medical devices into a Iran
  • Are PVC plasticizers harmful to patients?
  • The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evalu … Migrability of PVC plasticizers from medical devices into a simulant of infused solutions Int J Pharm.
  • Are plasticizers in the PVC matrix a risk factor for patient exposure?
  • The plasticizers in the PVC matrix can leach out into the infused solutions and may enter into contact with the patients. In order to assess the risk of patient exposure to these plasticizers we evaluated the migration performance of DEHP, DEHT, DINCH, and TOTM using a model adapted to the clinical use of the MDs.
  • Does the migration of plasticizers vary with the type of medical device?
  • The results highlight that the migration of plasticizers varies greatly with the type of medical device.
  • How many plasticizers are released during migration assays?
  • Quantity of plasticizers released during migration assays from the 4 infusion sets tested (n = 3, mean +/- standard deviation). The quantity of plasticizers released into the simulant raises gradually during the infusion period, regardless the type of device and the plasticizer integrated into the PVC.
  • Does flow rate affect migrability of plasticizers?
  • The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated.
  • How are plasticizers analyzed in PVC tubings?
  • Chromatographic analyses of both the plasticizers in the PVC tubings after solvent extraction (before migration tests) and in the simulant after contact with the samples (specific migration) were performed according to the analytical method described by Bernard et al. (2015).

Recommended hot-selling products