Pediatric Exposure and Potential Toxicity of Phthalate Plasticizers Pakistan

  • Pediatric Exposure and Potential Toxicity of Phthalate Plasticizers Pakistan
  • Pediatric Exposure and Potential Toxicity of Phthalate Plasticizers Pakistan
  • Pediatric Exposure and Potential Toxicity of Phthalate Plasticizers Pakistan
  • Are there phthalate plasticizers in children's products?
  • In recent decades, phthalate plasticizers in children’s products such as toys, teethers, and backpacks were analyzed in numerous studies [ 12, 13, 14, 15, 16, 17, 18 ]. They were found in various polymeric parts of a product, especially polyvinyl chloride (PVC).
  • How do children get exposure to phthalate?
  • In the case of children, exposure through diet was the dominant pathway explaining more than 40% of total exposure to DEHP, followed by the use of childcare products (>20%) and toys (>10%). Kim et al. analyzed phthalate metabolites in the urine of elementary school children of Korea [ 41 ].
  • How much phthalate can a neonatal & pediatric ICU patient be exposed to?
  • Neonatal and pediatric ICU patients can be exposed to multiple DEHP-containing plastic devices, which can result in a cumulative phthalate exposure of 16 mg/kg per day (Mallow & Fox, 2014). Such exposures can precipitate adverse health outcomes, including the cardiotoxic effects described in this review. 3.2 |.
  • Do phthalates from recycled plastics affect human health?
  • We found no reviews of epidemiological human studies on the impact of phthalates from recycled plastics on human health. We recommend that future research should use urine samples as exposure measures, consider confounders in analyses and measure impacts on female reproductive systems.
  • Is phthalate exposure a risk factor for neonatal infants?
  • With more than 3,000,000 infants admitted to the neonatal ICU each year in the United States, phthalate exposure from medical products is a considerable concern during this developmentally vulnerable period (FDA, 2002; Stroustrup et al., 2018).
  • How many phthalate plasticizers are in PVC toys?
  • Of the analyzed products, some had two or more phthalate plasticizers, but most products had one phthalate plasticizer. In the early 2000s, diisononyl phthalate (DINP) was the predominant phthalate plasticizer in PVC toys, of which concentration was up to 44%, and di (2-ethylhexyl)phthalate (DEHP) was the second-most dominant [ 12, 13 ].

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