Plasticizer At High Doses Disrupts Male Reproductive Function Indonesia

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:2432-87-3, 2432-87-3
Other Names:DOS
MF:C26H50O4
EINECS No.:219-411-3
Purity:99.6%
Type:Plasticizer DOS
Usage:Coating Auxiliary Agents, Petroleum Additives, Drilling mud chemicals
MOQ:1000KG
Color:Colorless transparent

In the 104-week feeding studies mentioned above, DEHP caused an increase in the mean relative brain weights in male B6C3F1 mice at the highest dose (6,000 ppm). A

from sciencedaily / releases / 1999 /

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Bisphenol A and Male Fertility: Myths and Realities PMC

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:2432-87-3
Other Names:DOS
MF:C26H50O4
EINECS No.:219-411-3
Purity:0.98
Type:Dioctyl sebacate
Usage:Coating Auxiliary Agents, Electronics Chemicals, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Surfactants
MOQ:200kgs
Color:Colorless transparent

Jin P, Wang X, Chang F, Bai Y, Li Y, Zhou R, et al. Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell

Studies investigating the effects of antioxidants on DEHP-mediated male reproductive toxicity typically use dose ranges from 20 to 2000 mg/kg bw/d over periods of

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Bisphenols and phthalates: Plastic chemical exposures can

Classification:Chemical Auxiliary Agent, Chemical Auxiliary Agent
CAS No.:2432-87-3, 2432-87-3
Other Names:DOS plasticizer
MF:C26H5004, C26H5004
EINECS No.:219-411-3
Purity:99%, ≥99.0%
Type:Plasticizer
Usage:Coating Auxiliary Agents, Electronics Chemicals, Leather Auxiliary Agents, Paper Chemicals, Petroleum Additives, Plastic Auxiliary Agents, Rubber Auxiliary Agents, Surfactants, Textile Auxiliary Agents, Water Treatment Chemicals, Coating Auxiliary Agents
MOQ:1000KG
Moisture(wt)%≤:0.1%

The Environmental Protection Agency’s reference dose for BPA is 0.05 mg kg −1 day −1 —which signifies an “estimate of a daily exposure to the human population (including sensitive

The potential for phthalates to affect thyroid function has been demonstrated in animal studies, but human studies are limited to two recent investigations: one within the Massachusetts

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Di-(2-ethylhexyl) phthalate exacerbates abnormalities of

Classification:Chemical Auxiliary Agent
CAS No.:2432-87-3, 2432-87-3
Other Names:DOS, DOS
MF:C26H5004, C26H5004
EINECS No.:219-411-3
Purity:99.6%
Type:PVC plasticizer
Usage:Coating Auxiliary Agents, Petroleum Additives, Drilling mud chemicals
MOQ:200kgs
Molecular weight:426.67

In utero exposure to high doses of DEHP (≥500 mg/kg) was observed to associated with male reproductive disorders in offspring mice, including impaired androgen

Phthalates have been identified by a number of studies and reviews as some of the most hazardous chemical additives in plastics for health, in terms of likelihood of impact by

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A Case–Control Study on the Effects of Plasticizers Exposure

Classification:Chemical Auxiliary Agent
CAS No.:2432-87-3, 2432-87-3
Other Names:DOS, DOS
MF:C26H5004, C26H5004
EINECS No.:219-411-3
Purity:99% Min
Type:Plasticizer
Usage:Plastic Auxiliary Agents
MOQ:200kgs
Molecular weight:426.67

Male infertility is a serious concern for public health, and the possible role of exposure to plasticizers such as phthalates and bisphenol A in contributing to the condition is

Although most research efforts have been placed on the impact of phthalates on male reproductive development and functions, Reproductive effects in F1 adult females exposed in utero to moderate to high doses of mono-2-ethylhexylphthalate (MEHP) Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1

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Does plasticizer exposure affect male and female reproductive health?
Results indicate that exposure to phthalates and bisphenol can adversely affect male and female reproductive health. However, evidence is still controversial. More large-scale prospective cohort studies are needed to verify the effects of plasticizer exposure on reproductive health in humans.
Do plastic additives affect reproductive and developmental outcomes?
Most studies to date have been cross-sectional in nature. Future longitudinal studies are needed to explore the temporal relationship between exposure to plastic additives and adverse reproductive and developmental outcomes to provide more information on whether these relationships may be causal in nature.
Does low-dose phthalate exposure affect human male genital development?
These findings suggest that AGD is a marker for insufficient foetal androgenization and suggest that low-dose phthalate exposure may affect several markers of human male genital development. (e). Human studies in adults (i). Semen quality Studies that have explored phthalate effects in adults are presented in table 4.
Is phthalate exposure associated with hypospadias in male births?
Overall, evidence from the epidemiological studies that estimate the association between phthalate exposure and hypospadias in male births is limited and inconclusive. Higher levels of phthalates have been found in women than in men, which revealed an aggregated phthalate exposure in females.
Should phthalate exposure be reduced among reproductive-aged women?
It is necessary to reduce phthalate exposure among reproductive-aged women as much as possible. Phthalate exposure is also associated with other aspects of reproductive health or has adverse effects.
Are plastics causing reproductive and developmental problems?
The leading hypothesis for these growing concerns is that certain chemicals, used in plastics to provide beneficial physical qualities, may also act as endocrine-disrupting compounds (EDCs) that could lead to adverse reproductive and developmental effects (NRC 1999).