Quantification of five plasticizers used in PVC tubing

  • Quantification of five plasticizers used in PVC tubing
  • Quantification of five plasticizers used in PVC tubing
  • Quantification of five plasticizers used in PVC tubing
  • Can We estimate the amount of plasticizer in PVC tubing?
  • Our extraction method demonstrates that it is possible to estimate the amounts of plasticizer in PVC tubing for all the plasticizers tested and should be suitable as a screening method for plasticizers used in tubing in marketed infusion devices.
  • What are the limits of quantification of PVC plasticizers?
  • The reported limits of quantification were 5 μg/mL and 25 ng/mL, respectively. After extraction from PVC tubes by diluting with THF and precipitating PVC with ethanol, the plasticizers were quantified by GC–MS with high sensitivity (LOD between 0.06 and 0.25 μg/mL and LOQ between 0.01 and 2.0 μg/mL, depending on the plasticizer).
  • How to quantify plasticizers in PVC medical devices?
  • The assays were validated according to the accuracy profile method. Plasticizers were extracted from PVC-tubing by dissolving PVC in THF then precipitating it in methanol with a yield of over 90% for each plasticizer. This assay could feasibly be used to quantify plasticizers in PVC medical devices.
  • How are plasticizers extracted from PVC-tubing?
  • Plasticizers were extracted from PVC-tubing by dissolving PVC in THF then precipitating it in methanol with a yield of over 90% for each plasticizer. This assay could feasibly be used to quantify plasticizers in PVC medical devices. 1. Introduction
  • Can plasticizers be extracted from PVC tubing?
  • Hence, the extraction yields (% w/w of PVC sample) from PVC tubing were 96.9 ± 2.5%, 103.7 ± 0.5%, 94.0 ± 1.6%, 90.6 ± 1.8% and 99.7 ± 0.5% for ATBC, DEHP, DEHT, DINCH and TOTM, respectively ( Table 5 ). Based on these results, this extraction technique seems to be adapted to the extraction of these plasticizers from PVC tubing. Table 5.
  • Which plasticizer is most commonly used?
  • Di- (2-ethylhexyl)-phthalate (DEHP) has been the most widely used plasticizer since its introduction in 1930. However, the non-covalent bond between DEHP (or plasticizers in general) and polymers mean they can be leached when they enter into contact with fluids containing lipophilic compounds .

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