Toxicity and molecular effects of di-n-butyl phthalate (DBP Serbia

  • Toxicity and molecular effects of di-n-butyl phthalate (DBP Serbia
  • Toxicity and molecular effects of di-n-butyl phthalate (DBP Serbia
  • Toxicity and molecular effects of di-n-butyl phthalate (DBP Serbia
  • How does di-n-butyl phthalate affect human health?
  • SUMMARY OF HEALTH EFFECTS The primary effects seen in animals following exposure to di- n -butyl phthalate are developmental and reproductive alterations. No data are available for developmental or reproductive effects in humans.
  • What is di-n-butyl phthalate (DBP)?
  • Di-n-butyl phthalate (DBP), a well-known EDC, is widely used in industrial productions. The use or disposal of plastics leads to ubiquitous exposure to DBP, which adversely affects male reproductive health 2.
  • Does di-n-butyl phthalate cause germ cell toxicity?
  • Provided by the Springer Nature SharedIt content-sharing initiative Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism of DBP-induced germ cells toxicity remains unclear.
  • Why is di n -butyl phthalate toxic?
  • A susceptible population will exhibit a different or enhanced response to di- n -butyl phthalate than will most persons exposed to the same level of di- n -butyl phthalate in the environment. Reasons may include genetic makeup, age, health and nutritional status, and exposure to other toxic substances (e.g., cigarette smoke).
  • Does di n -butyl phthalate cause respiratory effects?
  • Information on the potential of di- n -butyl phthalate to induce respiratory effects is limited to a study by Kawano (1980a), which found an increase in relative lung weight in rats exposed to 50 mg/m 3 di- n -butyl phthalate 6 hours/day for 6 months ( Kawano 1980a ); lung weight was not altered in the 0.5 mg/m 3 group.
  • Does di-n-butyl phthalate affect the liver?
  • Systemic, reproductive, and developmental effects have been observed in animals following oral exposure. The liver appears to be the most sensitive systemic target in rats and mice exposed to di- n -butyl phthalate in the diet for 13 weeks ( NTP 1995; Schilling et al. 1992 ).

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