Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate Switzerland

  • Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate Switzerland
  • Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate Switzerland
  • Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate Switzerland
  • When did EPA request a risk evaluation for Diisodecyl phthalate (DIDP)?
  • EPA received and granted manufacturer requests for risk evaluations of DINP and for diisodecyl phthalate (DIDP) in 2019. EPA released the draft risk evaluation for DIDP in May 2024 and requested peer review on the DINP human health hazard assessment at that time.
  • What are high molecular-weight phthalates (DINP) and diisodecyl phthalate (D?
  • High molecular-weight phthalates, such as diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP), are widely used as plasticizers in the manufacturing of polymers and consumer products. Human biological monitoring studies have employed the metabolites of DINP and DIDP as biomarkers to assess human exposure.
  • What is diisononyl phthalate (DINP)?
  • Policies and ethics Diisononyl phthalate (DINP) is one of the widely used dialkyl phthalate (DAPs) softeners in the production of flexible polyvinyl chloride (PVC) plastics, copolymers, and resins. These phthalate plasticizers are incorporated into the PVC polymer matrix to impart...
  • Does DINP cause phthalate syndrome?
  • However, DINP does have the potential to cause phthalate syndrome. Therefore, EPA is including DINP in its cumulative risk assessment along with five other phthalate chemicals that have the potential to cause phthalate syndrome, while DIDP is excluded from the cumulative risk assessment.
  • Does Di (isodecyl) phthalate induce peroxisomal proliferation?
  • Additional studies were also conducted on di (isodecyl) phthalate (DIDP), a structurally related substance that also induces peroxisomal proliferation, although it has not been tested in a carcinogenicity bioassay.
  • Does Di (isononyl) phthalate cause liver tumors?
  • Recently there have been reports of liver and kidney tumors in rodents following long-term exposure to di (isononyl) phthalate (DINP). Mechanistic studies suggested that the liver tumors were a consequence of peroxisomal proliferation, whereas the kidney tumors (found only in male rats) were associated with induction of alpha (2u)-globulin.

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