hot selling Topical Polymeric Films: Plasticizers

  • hot selling Topical Polymeric Films: Plasticizers
  • hot selling Topical Polymeric Films: Plasticizers
  • hot selling Topical Polymeric Films: Plasticizers
  • Are plasticizers used in transdermal drug delivery systems?
  • In transdermal therapeutic systems. It is observed that the plasticizers added to transdermal therapeutic systems are mostly used in the proportions between 5-20%. Following are the reasons which can be counted among those for adding plasticizers to the polymer films to be used in transdermal drug delivery systems:
  • How do Plasticizers improve physico-mechanical properties of polymeric films?
  • Plasticizers are low molecular weight resins or liquids that can improve physico-mechanical properties of polymeric films by weakening the intermolecular forces among the polymeric chains and forming new hydrogen bonds with them ( Sun et al., 2020 ).
  • Why are plasticizers added to pharmaceutical polymers?
  • Plasticizers are added to pharmaceutical polymers intending to ease the thermal workability, modifying the drug release from polymeric systems and improving the mechanical properties and surface properties of the dosage form (Felton, 2007; Lin et al., 2000; Wang et al., 1997; Wu & McGinity, 1999; Zhu et al., 2002).
  • What is a polymeric film?
  • Polymeric films, polymeric membranes, thin films, and polymeric adhesives are some of the same names for a drug delivery system capable of being placed on target tissue and having its effect. They are films made of polymers that can adhere to skin [ 1] and mucosal tissues, including ophthalmic [ 2 ], vaginal [ 3 ], and oral [ 4] cavities.
  • What are the excipients needed to make polymeric films?
  • Beyond the polymers, there are excipients necessary for producing the polymeric films. The plasticizers improve the mechanical properties of the films. With them, the elongation and the tensile strength are enhanced. The most common plasticizers are glycerols, triethyl and tributyl citrates, and diethyl phthalate [ 26 ].
  • How do plasticizers reduce film forming temperature?
  • Plasticizers reduce the minimum film-forming temperature and facilitate the formation of flexible films by lowering Tg of polymeric films and allowing inter-molecular interactions between the polymer and plasticizer via hydrogen bonding ( Vuddanda et al., 2017 ).

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